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DN\²åZó"í„)Î2‹[D 
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P„õ¡+=~Öâú{°À/ËcpHl�BUœÀ'7I³ü]¶N³+ o3`g«ÑÚQwþÝüg
—¯‹ŽÑ4Ð^�@CËí)?ËjÇQÊéî6
 [ ¶£ 	h˜%†  •/9Ë>Öi É Ë ‹ÙY[&8œ
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lnŸ%|šy¨m´)i {ˆ]cžº	n
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9Y¼Âò ; ïï[`ˆ	“ˆìé‡<õ C X _ žå	MTãMý‰ ÃWÁ3Y�:Gª9¦ t"[}>C¾ r™Ù	Ù
�â®2Ä�+™S°Ý `¥HX)Â‘öC*cr9P“  EM¢Ž	3
ÜjS¥mÄ+† ée  * í â®Ç^ O	 !Mè3FW¿ ý 1£âhüÜŽ,Á	Ê	xúšõ¼Ï˜! 	 F ö (_RÐÙ’æ˜ÜžC	¼	
ÐÕáòƒ¯?GÊiû\² ‡Š.ÿm
$xå§$h ã �¦ëè;ñ	 ½Àõ)bq˜’© ) ì õ -g‘Ûå�—B	l
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a:  &è  qGACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,GCACCCANNNGTT,AACNNNTGGGTGC,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,CACCCA,TCGGTC,TGGGTG,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                                                                                                                                                                                                                                                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                                                       
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          	          	 
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  t`mjõ²ÄŽ;öÜÚ/yà`]�ŽÆQ 4	7	Æéi¥-’	Ë’	’	’’»� ��¤·pÛ	£Êzn� ß tVõNt!
öÔ+H•« ¢PŒ¢PX Í±
ÿI«î-EÁ…¥MÎe	u	QµÕžÆq× ñÑÚÊmÉí ¯h}¸³s‘ŸsŸ¦¶ß oß sŸ˜ß ³› À{,ÓÜ,•À© ¿ÐNmåºß à ˜¢Pt”»ToiF°§‚ž¦Ãÿƒ+9�÷Þx]<ˆ"©j 	ˆíß ³s‘Ÿ‹	ü
	 Ô+H•ƒ+� » Z hIVåu¥žð 
§‚˜ºë÷MX0¦žˆËr	RÛn–ªäÿ‘L³ÑÚÊÍpA«ðÄQlð\¡ ÆÀÔ+lyHðs•*U\Æ$[Ÿ• ¯·'Æó�Ÿéò‹	ü
+gšþÍÙ	S¦jðçóv•cž²	ã�…¶© ²	¶ÉíTiot� 
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®Æ²ý«½HâŒJš¢èÙ†ñ:ÿa”Läî¤ï S‹I&~Yjnv¿©%È—«Õ©ÕL{dZjûò•–F^iU‘Öz;e%ÂzVŠž È«hèa^©%t¡Æk±¡ýªÕ'&dëÖjnÛˆ&	J¦”wŠž¨*A…M¯84éMhálG¡"5_äŠÂoPœè‘o®µÖÑ‘‹G6­U÷ª¥–¢#¥`”{õÖ©Ÿ¸¨¤¡^$YºZT‡q&´ªZ«‡JF.ZÖG)ø©éªOJ²ÊV?©ø¯Z²W	°«ªVµ¢©¦ ¡'ª·²•R¨Eš¦j¢¶%·¾ºZuj¤Û–¥ëZù¦uZ¥ãyµÝî”¨ë”ºjö^º§*óÚê8«©†`�KMÅÜ_.›¿i›ª¨Þ›jÊ«ªˆÎºTIkkà£V¨Uóœvê®WšÙ.©œªn¤U¨êaa±ô5Š¬úî,æâŒu†‰¨èªU+MuªWŽª©¸£Þµ[&Æ¹–¥PnBoª†[¶U¿¥ÈJ¬¯xL´ÉFÕë¡êªã2[Ž:5uU}óŸL ¨¨ðmDç×º«Å	x:ÓDÍõgŠë’$òJCßzÔ^âMóçgìî9oŠ} ã�H1”².Ÿ�íG)ðeÓ…À²7tý:ÅÇç|^Ÿ�2˜EL÷:üPPÁÐ›ÂSÁt3q:ô W>	º™/‹¬÷î„Ë¨†;- æW=5Ì>ªp¯ƒêŽª;v+«ã)¿á® eòióê†|ìóO4Ä´„ÄÁDË‘le:4,eh"¦î‚ËG†      Å  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  r<?xml version="1.0"?><Features nextValidID="2"><Feature recentID="1" name="135-10" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="87-122" color="#a6acb3" type="standard"/></Feature><Feature recentID="0" name="ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5233-5821" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
  ¦<?xml version="1.0"?><Primers nextValidID="2"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/><Primer recentID="0" name="L4440" sequence="AGCGAGTCAGTGAGCGAG" description="L4440 vector, forward primer"><BindingSite location="5974-5991" boundStrand="0" annealedBases="AGCGAGTCAGTGAGCGAG" meltingTemperature="58"><Component hybridizedRange="5974-5991" bases="AGCGAGTCAGTGAGCGAG"/></BindingSite><BindingSite simplified="1" location="5974-5991" boundStrand="0" annealedBases="AGCGAGTCAGTGAGCGAG" meltingTemperature="58"><Component hybridizedRange="5974-5991" bases="AGCGAGTCAGTGAGCGAG"/></BindingSite></Primer><Primer recentID="1" name="pBR322ori-F" sequence="GGGAAACGCCTGGTATCTTT" description="pBR322 origin, forward primer"><BindingSite location="5721-5740" boundStrand="0" annealedBases="GGGAAACGCCTGGTATCTTT" meltingTemperature="56"><Component hybridizedRange="5721-5740" bases="GGGAAACGCCTGGTATCTTT"/></BindingSite><BindingSite simplified="1" location="5721-5740" boundStrand="0" annealedBases="GGGAAACGCCTGGTATCTTT" meltingTemperature="56"><Component hybridizedRange="5721-5740" bases="GGGAAACGCCTGGTATCTTT"/></BindingSite></Primer></Primers>
  <Notes>
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<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pIB184 (EM)</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Description>E. coli - Streptococci shuttle plasmid for gene expression in streptococci with P23 promoter.</Description>
<Created UTC="0:47:26">2021.5.13</Created>
<LastModified UTC="8:16:23">2024.3.20</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
<References>
<Reference authors="Biswas I, Jha JK, Fromm N" pubMedID="18667560" title="Shuttle expression plasmids for genetic studies in Streptococcus mutans." journal="Microbiology. 2008 Aug;154(Pt 8):2275-82. doi: 10.1099/mic.0.2008/019265-0."/>
</References>
</Notes>
  (ý7zXZ  æÖ´F !   t/å£àÒå] Ë‡ØÎf‘ƒÊý{3Ôé·Ú(1v%f M*	mj÷)p80çÌ*iÚ	´NY]Qó“�úF7î&ƒÕ!Ò÷ÀnÚê¸#òþ,64JFìt¥¨‘u>…†æ%¯…³½p%V+°`ñMä×ÊiÎ_¹õ nS÷ókDø’[wý‰,ö4þ§½þ•ÖPu‡Iâ…š‘°À
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  8<?xml version="1.0"?><Features nextValidID="3"><Feature recentID="0" name="P23" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="230-408" color="#ffffff" type="standard"/></Feature><Feature recentID="1" name="135-10" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="316-351" color="#a6acb3" type="standard"/></Feature><Feature recentID="2" name="ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5462-6050" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
  ž<?xml version="1.0"?><Primers nextValidID="2"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/><Primer recentID="0" name="L4440" sequence="AGCGAGTCAGTGAGCGAG" description="L4440 vector, forward primer"><BindingSite location="117-134" boundStrand="0" annealedBases="AGCGAGTCAGTGAGCGAG" meltingTemperature="58"><Component hybridizedRange="117-134" bases="AGCGAGTCAGTGAGCGAG"/></BindingSite><BindingSite simplified="1" location="117-134" boundStrand="0" annealedBases="AGCGAGTCAGTGAGCGAG" meltingTemperature="58"><Component hybridizedRange="117-134" bases="AGCGAGTCAGTGAGCGAG"/></BindingSite></Primer><Primer recentID="1" name="pBR322ori-F" sequence="GGGAAACGCCTGGTATCTTT" description="pBR322 origin, forward primer"><BindingSite location="5950-5969" boundStrand="0" annealedBases="GGGAAACGCCTGGTATCTTT" meltingTemperature="56"><Component hybridizedRange="5950-5969" bases="GGGAAACGCCTGGTATCTTT"/></BindingSite><BindingSite simplified="1" location="5950-5969" boundStrand="0" annealedBases="GGGAAACGCCTGGTATCTTT" meltingTemperature="56"><Component hybridizedRange="5950-5969" bases="GGGAAACGCCTGGTATCTTT"/></BindingSite></Primer></Primers>
  ž<Notes>
<UUID>cb749760-db2a-4d96-93a3-f7e898179594</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pIB184 (EM)</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Description>E. coli - Streptococci shuttle plasmid for gene expression in streptococci with P23 promoter.</Description>
<Created UTC="0:47:26">2021.5.13</Created>
<LastModified UTC="8:18:12">2024.3.20</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
<References>
<Reference authors="Biswas I, Jha JK, Fromm N" date="2008-08" volume="154(Pt 8):2275-82. doi" title="Shuttle expression plasmids for genetic studies in Streptococcus mutans." type="Journal Article" pubMedID="18667560" journal="Microbiology. 2008 Aug;154(Pt 8):2275-82. doi: 10.1099/mic.0.2008/019265-0." pages=" 10.1099/mic.0.2008/019265-0" journalName="Microbiology."/>
</References>
</Notes>
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